Immunosenescence in Autoimmune Related to Periodontal Disease : A Review Article

 

Abstract

Introduction: Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by the development of autoantibodies and immune complexes associated with a variety of clinical manifestations and tissue damage. SLE is the production of reactive antibodies against the body’s own cells. SLE is multifactorial and most likely involves complex interactions between genetic, environmental, and hormonal factors. There is an aging process in immune cells due to changes in the innate and adaptive immune system compartments. This phenomenon is known as Immunosenescence, also occurs on autoimmune. One of the characteristics of elderly people is their inability to respond to vaccines and infections properly.

Discussion This situation also occurs in patients with systemic lupus erythematosus (SLE). In SLES patients, the aging of the immune system is the concept of inflammation; a state where there is a chronic pro-inflammatory status, characterized by increased levels of pro-inflammatory cytokines such as TNF, or IL-6, thereby stimulating a decrease in IL-2 and IFNγ and an increase in IL-10. Clotting factor and acute phase reactants under constant conditions. These biomarkers correlate with the incidence of various age-related diseases, such as heart disease, cognitive decline, cancer, and other physical disabilities. Immunosenescence and inflammation are the result of disruption in the cellular immunity properties of the innate and adaptive immune.

Conclusion: Defect production of T cells and B cells in autoimmune disease could results immune aging. This phenomenon causes neutrophil activation, forming antibody DNA consisting of immune complexes resulting in severe inflammation and tissue damage, as periodontal disease in oral cavity.

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